I would create a "EPIC EPIC" Purchasing Class on IC07 and change the items in question to that class on IC11.
Then use uploads to change all requesters to Validation Option 1 (Disallowed Purchase Classes) - not the 0 it defaults to.
Add Company and Major Minor EPIC EPIC
All other purchasing classes - even blank ones - will be allowed for the requester. It would only be items with EPIC EPIC on IC11 that the user would not be allowed to add.
We have one set for IT Equipment - screen shot attached.